“Biomedical Engineering is the application of engineering principles and design concepts to medicine and biology. This field seeks to close the gap between engineering and medicine: It combines the design and problem solving skills of engineering with medical and biological sciences to improve healthcare and diagnosis, monitoring and therapy… Prominent biomedical engineering applications include the development of biocompatible prostheses, various diagnostic and therapeutic medical devices ranging from clinical equipment to micro-implants, common imaging equipment such as MRIs and EEGs, regenerative tissue growth, pharmaceutical drugs and therapeutic biologicals” (Wikipedia). I sat down with UMD’s own Dr. Darayash Tata, physics professor and biomedical engineer, to hear about the research he does at the university. Dr. Tata’s research seeks to solve the same problem that many other biomedical engineers obsess over, cancer. Cancer is one of the biggest fears of American society. It is one of the few common diseases that is still terminal to this day. Though a great amount of research has been done on the disease, methods used to prevent and “cure” it are not entirely effective and can harm the body greatly. When considering curing cancer, one would typically think of a doctor in a hospital. Though biomedical engineers help cure disease as much as doctors do, their work is far different and rarely thought about. Dr. Tata seeks to cure medical problems by the engineering devices.
Dr. Tata has been researching a method of destroying cancerous tissue by the use of light. Research has shown that photo-agent Photofrin II tends to be retained by cancerous tissue. When the body is injected with Photo II nanoparticles, all tissue tends to retain some of them for a certain period of time. Healthy tissue is able to quickly flush the particles out within 40 to 50 hours. Tumors however, do not flush the Photofrin II out for a greater period of time. Thus, the photofrin II particles remain dormant within the tumor. The nanoparticles are biologically inert without the presence of visible light. “In the presence of visible light and molecular oxygen Photo II is known to induce “dynamical killing””(Tata, 3). The “dynamical killing” is performed through oxygen-based reactions, destroying much of the cancerous tumor. According to Dr. Tata, the largest setback inherent to this method of destroying cancer is the lack of oxygen within cancerous cells. Ultimately, the tumor is destroyed to a certain extent but is limited by the amount of oxygen available. The reactions causing the “dynamical killing” subside as soon as the tumor runs out of oxygen. It is for this reason that cancer is not widely treated with this device. Through time and research, Dr. Tata hopes to refine this method. If it can be made more efficient and cost-effective, this method could greatly help cancer patients.
Biomedical engineering is a relatively new field combining theories of biology, medicine, and engineering. Biomedical engineers can be greatly credited for the vast advances in medicine over the past couple decades. By applying what we know about biology and medicine, doctors with sound engineering backgrounds can create devices to overcome our greatest medical problems. Through his research, Dr. Tata intends to do just that: Engineer a device that will destroy cancerous tumors.
**I could not get this video embedded http://qik.com/video/45873839